An Adamant nature is chosen over Jolly because Mightyena needs the extra power due to its low offenses, but Jolly allows Mightyena to outspeed faster Ghost- and Psychic-type such as Adamant or Modest Drifblim and Modest Gardevoir. BlackGlasses is the preferred item as it gives Mightyena the power to guarantee a 2HKO against Musharna after Stealth Rock and to OHKO against Muk after two boost and Stealth Rock. Lum Berry also has some good uses, as it helps Mightyena against Jynx and lets it switch in on status moves from Pokemon such as Musharna and Misdreavus. Howl can also be used over Taunt or Toxic, allowing Mightyena to get a boost behind a Substitute or from a forced switch and OHKO Pokemon such as Roselia and Misdreavus, but Taunt and Toxic's support from Mightyena is more useful most of the time. Life Orb can also be used over BlackGlasses or Lum Berry, as it gives Mightyena more power, but Mightyena will faint quickly with the Life Orb recoil and Substitute.